Genetic causes of miscarriage and karyotype analysis
The coming pregnancy is a great joy in the life of the family. Every woman dreams that her baby is born healthy, and here the proper nutrition and lifestyle of the future mother is very important. Unfortunately, this is sometimes not enough. The most common cause of miscarriage is chromosomal abnormalities of the fetus, which are the basis of 60-65% of miscarriages that occurred in terms of up to 10 weeks of pregnancy. Early detection of genetic abnormalities of the fetus helps karyotyping.
What does karyotype analysis reveal?
A karyotype is a set and structure of chromosomes that are characteristic of every living organism. Any anomaly in the chromosomal structure carries serious consequences in the development of the human body even at the prenatal stage, this becomes one of the main reasons for miscarriage.Karyotyping is based on the cytogenetic method, makes it possible to analyze the structure and number of chromosomes of the fetus, to detect disorders (excess chromosome, exchange of fragments of different chromosomes, loss of one chromosome), which can cause miscarriage of pregnancy / infertility or indicate a high risk of having a baby with severe congenital pathologies.
Molecular karyotyping using microarrays
Karyotyping is a classic research method that has been used for several decades. Currently, an improved, innovative research method has emerged - molecular karyotyping. It is based on the use of equipment that “reads” microarrays with a high density of oligonucleotide probes. Such a prenatal DNA test greatly increases the accuracy and efficiency of karyotyping. Diagnosis is shown to future parents when planning pregnancy, children for postnatal and neonatal diagnostics, pregnant women as prenatal diagnostics.
Karyotype analysis is not the only way to detect chromosomal abnormalities, today there is a safe non-invasive DOT test with more than 99.7% certainty that determines aneuploidy on the most common chromosomes (Klinefelter syndrome, Shereshevsky-Turner syndrome, Patau syndrome, Edwards syndrome, Down syndrome) . What kind of research is necessary to pass a woman who is at risk of fetal chromosomal abnormalities, the geneticist decides.
Micrometric karyotyping and DOT-test are used in practical medicine relatively recently - since 2013, therefore the number of medical institutions that use such diagnostic methods is limited. Today in Russia there is only one place where you can make a non-invasive diagnosis of basic trisomy and make an analysis of the karyotype using microarmatrix - this is the Moscow laboratory "Genoanalitika". Pregnant women from other regions of the Russian Federation can donate blood for the DOT test using existing logistic programs.
Take care of your baby before birth. Health to you and your child!
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