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Your Favorite Relaxation Habit Might Be Secretly Screwing With Your Meds
Antidepressant Medications, or SSRIs and SNRIs
“The key point here is that cannabis is fundamentally a psychoactive compound,” says Brennan. “People use it because it exerts its action on the brain, on the central nervous system receptors.” But antidepressant medications—the most common of which are selective serotonin reuptake inhibitors (SSRIs), like Zoloft (or sertraline) or Celexa (or ditalopram), and serotonin norepinephrine reuptake inhibitors (SNRIs), like Cymbalta (or duloxetine)—also exert psychoactive effects on some of the same receptors.
“The challenge for people who have mood disorder or depression is that every time they’re using cannabis, they’re taking another psychoactive drug,” says Brennan. “And that can make it very challenging for a patient or physician to figure out what drug is actually having an effect on what.” Plus, he adds, the cannabis could actually negate the positive effects of prescription medication.
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Anti-Anxiety Medications, or Benzodiazepines
Anti-anxiety medications like Ativan (Lorazepam), Klonopin (Clonazepam), or Xanax (Alprazolam) are all part of a class of medications called benzodiazepines, says Brennan. “Again, you have two psychoactive compounds interacting with each other in the brain,” he says. “If somebody’s really struggling with anxiety, I’d like to know what products are going in their brain so I can better understand how I’m medicating them. But if they’re smoking cannabis at the same time as using Ativan or Klonopin, it’s really hard to figure out what’s going on.”
A lot of people will smoke marijuana and say, “This is the only thing that helps my anxiety!” Other people will say they’re never more paranoid than when they smoke pot. That’s true for prescription drugs, too—people have different reactions to different products. “The challenge with cannabis is there’s no scientific data out there to say it tested against Ativan or Klonopin—the data doesn’t exist,” says Brennan.
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You’re already aware that mixing alcohol with sleeping pills is a bad idea. Same goes for pot. “This depends on how much cannabis someone is using and what effect cannabis has on them, but mixing any product that with the opportunity to sedate someone or alter their consciousness is potentially dangerous,” says Brennan. “When you combine cannabis with a sedative hypnotic like Zolpidem or Ambien, I think people could perhaps find themselves in a very usual psychological state.”
If you’ve been prescribed sleeping medication, whether you use it regularly or just to get through those tough red-eye flights, you’re better off sticking to just the prescription medication for the duration of the dose, versus mixing it with cannabis or any other drugs.
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Allergy and Cold Meds
You might think that allergy and cold medicines like Benadryl (diphenhydramine) or Mucinex (guaifenesin) are NBD because you can grab them straight off the drugstore shelves—but if you take them with marijuana, they could have unanticipated effects.
“Benadryl, or allergy and cold meds, are sedative products,” says Brennan. “Some people can take them and go about their day, others take one dose and they’re on the couch for the rest of the day. I think it’s really important for people to remember that cannabis is not a harmless product, and we don’t know how it might interact with even over-the-counter drugs.”
So if you’re sick, stick to just one drug (the cold meds, please) if you want it to work its magic as fast as possible.
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